Yes, absolutely safe! There are no poisons, harsh chemicals, or neurotoxins of any kind. The formula is built entirely from 100% natural, plant-based ingredients — specifically Citronella Oil and Lemongrass Oil, along with our proprietary slow-release complex. It is designed to be completely harmless and gentle around humans, pets, and livestock, while being highly effective at repelling spiders. You can place these pouches around your home with complete peace of mind.